Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
cnr2_human | 341 | C-term | E => GlyfsTer2 | frameshift | 8.241e-06 | 1 | 121346 | 0 | None | None | ||
cnr2_human | 257 | 6.47x47 | TM6 | C => GlyfsTer20 | frameshift | 8.24e-06 | 1 | 121354 | 0 | None | None | |
cnr2_human | 255 | 6.45x45 | TM6 | L => SerfsTer66 | frameshift | 8.24e-06 | 1 | 121356 | 0 | None | None | |
cnr2_human | 236 | ICL3 | R => Ter | stop gained | 0.0001822 | 22 | 120734 | 0 | None | None | ||
cnr2_human | 194 | 5.43x43 | TM5 | W => Ter | stop gained | 8.549e-06 | 1 | 116970 | 0 | None | None | LB (aromatic (edge-to-face), hydrophobic, Van der Waals, aromatic (face-to-edge)) |
cnr2_human | 132 | 3.51x51 | TM3 | Y => Ter | stop gained | 2.473e-05 | 3 | 121288 | 0 | None | None | |
cnr2_human | 131 | 3.50x50 | TM3 | R => Ter | stop gained | 0.0002144 | 26 | 121294 | 0 | None | None | SodiumPocket MicroSwitch GP (contact) |
cnr2_human | 63 | 12.49x49 | ICL1 | Q => Ter | stop gained | 8.244e-06 | 1 | 121298 | 0 | None | None | |
cnr2_human | 5 | N-term | W => Ter | stop gained | 1.759e-05 | 2 | 113718 | 0 | None | None | ||
cnr2_human | 357 | C-term | L => F | missense | 1.667e-05 | 2 | 119990 | 0 | nan | 0.0 | ||
cnr2_human | 354 | C-term | D => H | missense | 2.489e-05 | 3 | 120532 | 0 | nan | 0.135 | ||
cnr2_human | 352 | C-term | S => C | missense | 8.278e-06 | 1 | 120800 | 0 | 0.01 | 0.635 | PTM (Phosphorylation) | |
cnr2_human | 348 | C-term | P => L | missense | 8.252e-05 | 10 | 121184 | 0 | 0.41 | 0.0 | ||
cnr2_human | 342 | C-term | A => T | missense | 8.241e-06 | 1 | 121346 | 0 | 0.11 | 0.004 | ||
cnr2_human | 339 | C-term | E => K | missense | 8.238e-06 | 1 | 121382 | 0 | 0.09 | 0.04 | ||
cnr2_human | 338 | C-term | T => I | missense | 4.118e-05 | 5 | 121406 | 0 | 0.27 | 0.031 | PTM (Phosphorylation) | |
cnr2_human | 335 | C-term | S => F | missense | 8.237e-06 | 1 | 121406 | 0 | 0.02 | 0.99 | PTM (Phosphorylation) | |
cnr2_human | 333 | C-term | P => R | missense | 8.237e-06 | 1 | 121404 | 0 | 0.11 | 0.257 | ||
cnr2_human | 330 | C-term | E => K | missense | 4.942e-05 | 6 | 121404 | 0 | 0.1 | 0.001 | ||
cnr2_human | 328 | C-term | A => V | missense | 2.471e-05 | 3 | 121406 | 0 | 0.19 | 0.013 | ||
cnr2_human | 328 | C-term | A => T | missense | 1.647e-05 | 2 | 121406 | 0 | 0.4 | 0.001 | ||
cnr2_human | 325 | C-term | G => E | missense | 8.237e-06 | 1 | 121404 | 0 | 0.4 | 0.019 | ||
cnr2_human | 325 | C-term | G => R | missense | 8.237e-06 | 1 | 121406 | 0 | 0.16 | 0.015 | ||
cnr2_human | 320 | C-term | C => Y | missense | 1.647e-05 | 2 | 121402 | 0 | 1.0 | 0.0 | ||
cnr2_human | 320 | C-term | C => R | missense | 8.237e-06 | 1 | 121398 | 0 | 0.36 | 0.0 | ||
cnr2_human | 316 | 8.60x60 | H8 | H => Y | missense | 0.09724 | 11804 | 121392 | 700 | 1.0 | 0.05 | |
cnr2_human | 316 | 8.60x60 | H8 | H => N | missense | 1.648e-05 | 2 | 121392 | 0 | 0.34 | 0.001 | |
cnr2_human | 315 | 8.59x59 | H8 | A => V | missense | 2.471e-05 | 3 | 121402 | 0 | 0.2 | 0.004 | |
cnr2_human | 313 | 8.57x57 | H8 | C => Y | missense | 8.237e-06 | 1 | 121402 | 0 | 1.0 | 0.032 | |
cnr2_human | 308 | 8.52x52 | H8 | S => F | missense | 8.237e-06 | 1 | 121402 | 0 | 0.08 | 0.653 | |
cnr2_human | 307 | 8.51x51 | H8 | R => H | missense | 1.647e-05 | 2 | 121404 | 0 | 0.05 | 0.063 | GP (contact) |
cnr2_human | 307 | 8.51x51 | H8 | R => C | missense | 1.647e-05 | 2 | 121404 | 0 | 0.02 | 0.037 | GP (contact) |
cnr2_human | 307 | 8.51x51 | H8 | R => G | missense | 8.237e-06 | 1 | 121404 | 0 | 0.01 | 0.524 | GP (contact) |
cnr2_human | 306 | 8.50x50 | H8 | I => V | missense | 8.237e-06 | 1 | 121402 | 0 | 0.06 | 0.012 | |
cnr2_human | 302 | 7.56x56 | TM7 | R => W | missense | 8.237e-06 | 1 | 121402 | 0 | 0.02 | 1.0 | GP (contact) |
cnr2_human | 297 | 7.51x51 | TM7 | V => I | missense | 8.237e-06 | 1 | 121400 | 0 | 1.0 | 0.004 | |
cnr2_human | 290 | 7.44x43 | TM7 | I => V | missense | 8.237e-06 | 1 | 121400 | 0 | 1.0 | 0.0 | SodiumPocket MicroSwitch |
cnr2_human | 285 | 7.39x38 | TM7 | S => F | missense | 8.237e-06 | 1 | 121398 | 0 | 0.0 | 0.983 | LB (polar (hydrogen bond), Van der Waals) |
cnr2_human | 280 | 7.34x33 | TM7 | A => V | missense | 0.0006096 | 74 | 121382 | 0 | 1.0 | 0.004 | |
cnr2_human | 275 | 7.29x28 | TM7 | D => E | missense | 8.24e-06 | 1 | 121366 | 0 | 0.22 | 0.015 | |
cnr2_human | 275 | 7.29x28 | TM7 | D => A | missense | 1.648e-05 | 2 | 121366 | 0 | 0.07 | 0.257 | |
cnr2_human | 272 | ECL3 | T => M | missense | 9.064e-05 | 11 | 121358 | 0 | 0.05 | 0.873 | ||
cnr2_human | 271 | 6.61x61 | TM6 | T => A | missense | 8.24e-06 | 1 | 121356 | 0 | 1.0 | 0.001 | |
cnr2_human | 270 | 6.60x60 | TM6 | A => D | missense | 8.24e-06 | 1 | 121358 | 0 | 0.06 | 0.295 | |
cnr2_human | 266 | 6.56x56 | TM6 | A => S | missense | 1.648e-05 | 2 | 121350 | 0 | 0.02 | 0.077 | |
cnr2_human | 265 | 6.55x55 | TM6 | M => R | missense | 1.648e-05 | 2 | 121352 | 0 | 0.0 | 0.912 | LB (hydrophobic, Van der Waals) |
cnr2_human | 254 | 6.44x44 | TM6 | L => F | missense | 0.0001648 | 20 | 121346 | 0 | 0.0 | 0.969 | SodiumPocket MicroSwitch |
cnr2_human | 250 | 6.40x40 | TM6 | V => L | missense | 8.246e-06 | 1 | 121274 | 0 | 0.2 | 0.09 | GP (contact) |
cnr2_human | 248 | 6.38x38 | TM6 | G => V | missense | 8.247e-06 | 1 | 121250 | 0 | 0.3 | 0.487 | |
cnr2_human | 248 | 6.38x38 | TM6 | G => R | missense | 1.65e-05 | 2 | 121246 | 0 | 0.07 | 0.993 | |
cnr2_human | 244 | 6.34x34 | TM6 | A => D | missense | 8.252e-06 | 1 | 121176 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch |
cnr2_human | 244 | 6.34x34 | TM6 | A => V | missense | 0.000132 | 16 | 121176 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch |
cnr2_human | 242 | 6.32x32 | TM6 | R => S | missense | 8.259e-06 | 1 | 121084 | 0 | 0.01 | 0.345 | GP (contact) |
cnr2_human | 242 | 6.32x32 | TM6 | R => M | missense | 8.26e-06 | 1 | 121062 | 0 | 0.21 | 0.078 | GP (contact) |
cnr2_human | 236 | ICL3 | R => Q | missense | 4.141e-05 | 5 | 120742 | 0 | 0.23 | 0.908 | ||
cnr2_human | 236 | ICL3 | R => G | missense | 8.283e-06 | 1 | 120734 | 0 | 0.02 | 0.945 | ||
cnr2_human | 233 | ICL3 | G => E | missense | 8.291e-06 | 1 | 120610 | 0 | 0.46 | 0.825 | ||
cnr2_human | 229 | ICL3 | R => K | missense | 8.304e-06 | 1 | 120426 | 0 | 0.35 | 0.01 | ||
cnr2_human | 228 | ICL3 | D => N | missense | 2.492e-05 | 3 | 120370 | 0 | 0.51 | 0.01 | ||
cnr2_human | 218 | 5.67x67 | TM5 | Q => H | missense | 8.434e-06 | 1 | 118570 | 0 | 0.25 | 0.946 | GP (contact) |
cnr2_human | 218 | 5.67x67 | TM5 | Q => R | missense | 8.428e-06 | 1 | 118654 | 0 | 0.4 | 0.065 | GP (contact) |
cnr2_human | 216 | 5.65x65 | TM5 | A => V | missense | 5.066e-05 | 6 | 118440 | 0 | 0.0 | 1.0 | GP (contact) |
cnr2_human | 211 | 5.60x60 | TM5 | H => Q | missense | 8.461e-06 | 1 | 118196 | 0 | 0.11 | 0.422 | |
cnr2_human | 211 | 5.60x60 | TM5 | H => L | missense | 8.464e-06 | 1 | 118142 | 0 | 0.31 | 0.608 | |
cnr2_human | 210 | 5.59x59 | TM5 | G => R | missense | 8.476e-06 | 1 | 117986 | 0 | 0.14 | 0.882 | |
cnr2_human | 204 | 5.53x53 | TM5 | G => R | missense | 3.4e-05 | 4 | 117650 | 0 | 0.37 | 0.921 | |
cnr2_human | 203 | 5.52x52 | TM5 | S => C | missense | 8.503e-06 | 1 | 117608 | 0 | 0.2 | 0.017 | |
cnr2_human | 199 | 5.48x48 | TM5 | A => G | missense | 8.517e-06 | 1 | 117408 | 0 | 0.23 | 0.532 | |
cnr2_human | 199 | 5.48x48 | TM5 | A => T | missense | 9.378e-05 | 11 | 117298 | 0 | 0.44 | 0.025 | |
cnr2_human | 190 | 5.39x39 | TM5 | Y => C | missense | 8.573e-06 | 1 | 116644 | 0 | 0.0 | 0.999 | LB (polar (hydrogen bond), hydrophobic) |
cnr2_human | 186 | ECL2 | I => N | missense | 8.608e-06 | 1 | 116166 | 0 | 0.0 | 0.939 | ||
cnr2_human | 178 | ECL2 | P => T | missense | 2.594e-05 | 3 | 115670 | 0 | 1.0 | 0.026 | ||
cnr2_human | 174 | ECL2 | C => Y | missense | 8.648e-06 | 1 | 115638 | 0 | 0.0 | 1.0 | ||
cnr2_human | 164 | 4.56x56 | TM4 | V => I | missense | 8.547e-06 | 1 | 116994 | 0 | 1.0 | 0.023 | |
cnr2_human | 159 | 4.51x51 | TM4 | V => F | missense | 8.459e-06 | 1 | 118216 | 0 | 0.07 | 0.089 | |
cnr2_human | 158 | 4.50x50 | TM4 | W => C | missense | 8.449e-06 | 1 | 118354 | 0 | 0.0 | 1.0 | |
cnr2_human | 155 | 4.47x47 | TM4 | G => S | missense | 8.264e-06 | 1 | 121006 | 0 | 0.56 | 0.08 | |
cnr2_human | 154 | 4.46x46 | TM4 | L => V | missense | 8.262e-06 | 1 | 121036 | 0 | 0.01 | 0.982 | |
cnr2_human | 148 | 4.40x40 | TM4 | G => R | missense | 8.252e-06 | 1 | 121188 | 0 | 0.74 | 0.023 | |
cnr2_human | 147 | 4.39x39 | TM4 | R => H | missense | 6.602e-05 | 8 | 121178 | 0 | 0.09 | 0.04 | |
cnr2_human | 144 | 34.56x56 | ICL2 | L => Q | missense | 8.249e-06 | 1 | 121228 | 0 | 0.0 | 0.993 | GP (contact) |
cnr2_human | 142 | 34.54x54 | ICL2 | K => R | missense | 8.248e-06 | 1 | 121242 | 0 | 0.12 | 0.255 | GP (contact) |
cnr2_human | 139 | 34.51x51 | ICL2 | P => T | missense | 8.247e-06 | 1 | 121256 | 0 | 0.98 | 0.018 | GP (contact) |
cnr2_human | 137 | 3.56x56 | TM3 | Y => C | missense | 8.246e-06 | 1 | 121264 | 0 | 0.01 | 0.866 | PTM (Phosphorylation) GP (contact) |
cnr2_human | 136 | 3.55x55 | TM3 | R => H | missense | 5.773e-05 | 7 | 121258 | 0 | 1.0 | 0.002 | GP (contact) |
cnr2_human | 136 | 3.55x55 | TM3 | R => C | missense | 6.597e-05 | 8 | 121272 | 0 | 0.24 | 0.0 | GP (contact) |
cnr2_human | 134 | 3.53x53 | TM3 | C => Y | missense | 8.246e-06 | 1 | 121270 | 0 | 0.0 | 0.995 | GP (contact) |
cnr2_human | 133 | 3.52x52 | TM3 | L => I | missense | 0.003636 | 441 | 121284 | 3 | 0.9 | 0.721 | |
cnr2_human | 131 | 3.50x50 | TM3 | R => Q | missense | 2.474e-05 | 3 | 121278 | 0 | 0.0 | 1.0 | SodiumPocket MicroSwitch GP (contact) |
cnr2_human | 128 | 3.47x47 | TM3 | A => S | missense | 8.245e-06 | 1 | 121292 | 0 | 0.0 | 1.0 | |
cnr2_human | 119 | 3.38x38 | TM3 | A => D | missense | 8.242e-06 | 1 | 121336 | 0 | 0.0 | 0.991 | |
cnr2_human | 117 | 3.36x36 | TM3 | F => S | missense | 8.241e-06 | 1 | 121342 | 0 | 0.0 | 1.0 | LB (aromatic (face-to-edge), hydrophobic, Van der Waals) |
cnr2_human | 114 | 3.33x33 | TM3 | T => P | missense | 8.241e-06 | 1 | 121346 | 0 | 0.01 | 0.996 | PTM (Phosphorylation) LB (polar (hydrogen bond), Van der Waals) |
cnr2_human | 113 | 3.32x32 | TM3 | V => M | missense | 8.241e-06 | 1 | 121350 | 0 | 0.0 | 1.0 | LB (hydrophobic) |
cnr2_human | 111 | 3.30x30 | TM3 | G => S | missense | 1.648e-05 | 2 | 121348 | 0 | 0.02 | 0.975 | |
cnr2_human | 110 | 3.29x29 | TM3 | I => M | missense | 1.648e-05 | 2 | 121350 | 0 | 0.01 | 0.794 | LB (hydrophobic) |
cnr2_human | 110 | 3.29x29 | TM3 | I => T | missense | 0.0002555 | 31 | 121352 | 0 | 0.0 | 0.751 | LB (hydrophobic) |
cnr2_human | 101 | ECL1 | D => A | missense | 8.24e-06 | 1 | 121352 | 0 | 0.0 | 0.92 | ||
cnr2_human | 95 | 2.65x65 | TM2 | H => R | missense | 8.24e-06 | 1 | 121354 | 0 | 0.0 | 1.0 | |
cnr2_human | 92 | 2.62x62 | TM2 | V => M | missense | 8.24e-06 | 1 | 121354 | 0 | 0.0 | 0.968 | |
cnr2_human | 90 | 2.60x60 | TM2 | S => N | missense | 8.24e-06 | 1 | 121356 | 0 | 0.2 | 0.036 | |
cnr2_human | 89 | 2.59x59 | TM2 | C => Y | missense | 1.648e-05 | 2 | 121356 | 0 | 1.0 | 0.024 | |
cnr2_human | 89 | 2.59x59 | TM2 | C => R | missense | 8.24e-06 | 1 | 121358 | 0 | 0.18 | 0.039 | |
cnr2_human | 84 | 2.54x54 | TM2 | S => C | missense | 4.12e-05 | 5 | 121350 | 0 | 0.02 | 0.729 | |
cnr2_human | 74 | 2.44x44 | TM2 | G => C | missense | 8.24e-06 | 1 | 121358 | 0 | 0.0 | 0.975 | |
cnr2_human | 70 | 2.40x40 | TM2 | Y => H | missense | 4.944e-05 | 6 | 121354 | 0 | 0.01 | 0.995 | |
cnr2_human | 66 | ICL1 | R => Q | missense | 0.003504 | 424 | 121004 | 9 | 0.17 | 0.319 | ||
cnr2_human | 66 | ICL1 | R => W | missense | 4.128e-05 | 5 | 121114 | 0 | 0.01 | 0.991 | ||
cnr2_human | 65 | 12.51x51 | ICL1 | R => H | missense | 1.651e-05 | 2 | 121124 | 0 | 0.01 | 0.265 | |
cnr2_human | 65 | 12.51x51 | ICL1 | R => C | missense | 0.0001237 | 15 | 121238 | 0 | 0.01 | 0.993 | |
cnr2_human | 63 | 12.49x49 | ICL1 | Q => R | missense | 0.6182 | 74778 | 120970 | 23628 | 1.0 | 0.0 | |
cnr2_human | 63 | 12.49x49 | ICL1 | Q => K | missense | 8.244e-06 | 1 | 121298 | 0 | 0.86 | 0.0 | |
cnr2_human | 62 | 12.48x48 | ICL1 | H => R | missense | 8.243e-06 | 1 | 121310 | 0 | 0.8 | 0.002 | |
cnr2_human | 61 | 1.60x60 | TM1 | S => F | missense | 1.648e-05 | 2 | 121324 | 0 | 0.0 | 0.984 | |
cnr2_human | 52 | 1.51x51 | TM1 | V => M | missense | 5.772e-05 | 7 | 121270 | 0 | 0.19 | 0.013 | |
cnr2_human | 47 | 1.46x46 | TM1 | S => R | missense | 8.248e-06 | 1 | 121242 | 0 | 0.03 | 0.73 | |
cnr2_human | 40 | 1.39x39 | TM1 | C => Y | missense | 3.303e-05 | 4 | 121094 | 0 | 0.0 | 0.999 | |
cnr2_human | 30 | 1.29x29 | TM1 | G => D | missense | 9.938e-05 | 12 | 120750 | 0 | 0.68 | 0.002 | |
cnr2_human | 29 | 1.28x28 | TM1 | S => R | missense | 8.284e-06 | 1 | 120716 | 0 | 0.01 | 0.478 | PTM (Phosphorylation) |
cnr2_human | 22 | N-term | M => I | missense | 8.331e-06 | 1 | 120038 | 0 | 0.08 | 0.004 | ||
cnr2_human | 22 | N-term | M => V | missense | 2.501e-05 | 3 | 119954 | 0 | 0.03 | 0.049 | ||
cnr2_human | 22 | N-term | M => L | missense | 8.337e-06 | 1 | 119954 | 0 | 0.24 | 0.004 | ||
cnr2_human | 20 | N-term | N => S | missense | 2.507e-05 | 3 | 119646 | 0 | 0.57 | 0.007 | ||
cnr2_human | 18 | N-term | D => V | missense | 8.414e-06 | 1 | 118848 | 0 | 0.03 | 0.059 | ||
cnr2_human | 16 | N-term | G => V | missense | 8.457e-06 | 1 | 118244 | 0 | 0.03 | 0.157 | ||
cnr2_human | 15 | N-term | D => Y | missense | 4.245e-05 | 5 | 117788 | 0 | 0.04 | 0.428 | ||
cnr2_human | 11 | N-term | N => S | missense | 1.718e-05 | 2 | 116444 | 0 | 0.05 | 0.091 | ||
cnr2_human | 9 | N-term | I => M | missense | 8.64e-06 | 1 | 115736 | 0 | 0.18 | 0.029 | ||
cnr2_human | 9 | N-term | I => T | missense | 1.73e-05 | 2 | 115616 | 0 | 0.67 | 0.0 | ||
cnr2_human | 4 | N-term | C => Y | missense | 8.846e-06 | 1 | 113046 | 0 | 0.0 | 0.938 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue